Biochemistry ( Free PDF )

Cover image
Title page
Copyright
Preface to the Fourth Edition
Preface to the First Edition
Acknowledgements
The scope of biochemistry
Section One: Chemical Constituents of Life
Chapter 1: Biomolecules and the Cell
Chapter 2: Carbohydrates
Summary
Monosaccharides—structural aspects The structure of glucose
Disaccharides
Polysaccharides
Homopolysaccharides
Heteropolysaccharides
Agar and pectin
Glycoproteins
Self-assessment exercises
Chapter 3: Lipids
Summary
Fatty acids
Essential fatty acids
Triacylglycerols
Phospholipids
Glycolipids
Lipoproteins
Steroids
Amphipathic lipids
Soaps and detergents
Self-Assessment exercises
Chapter 4: Proteins and Amino Acids
Summary
Amino acids
The structure of proteins
Self-assessment exercises
Chapter 5: Nucleic Acids and Nucleotides
Chapter 6: Enzymes
Chapter 7: Vitamins
Section Two: Physiological Biochemistry
Chapter 8: Digestion and Absorption
Chapter 9: Plasma Proteins
Chapter 10: Hemoglobin and Porphyrins
Chapter 11: Biological Oxidation
Section Three: Metabolisms
Chapter 12: Introduction to Metabolism
Chapter 13: Metabolism of Carbohydrates
Chapter 14: Metabolism of Lipids
Chapter 15: Metabolism of Amino Acids
Chapter 16: Integration of Metabolism
Chapter 17: Metabolism of Nucleotides
Chapter 18: Mineral Metabolism
Section Four: Clinical Biochemistry and Nutrition
Chapter 19: Hormones
Chapter 20: Organ Function Tests
Chapter 21: Water
Chapter 22: Tissue Proteins and Body Fluids
Chapter 23: Nutrition
Section Five: Molecular Biology and Biotechnology
Chapter 24: DNA Replication
Chapter 25: Transcription and Translation
Chapter 26: Regulation of Gene Expression
Chapter 27: Recombinant DNA and Biotechnology
Section Six: Current Topics
Chapter 28: Human Genome Project
Chapter 29: Gene Therapy
Chapter 30: Bioinformatics
Chapter 31: Metabolism of Xenobiotics (Detoxification)
Chapter 32: Prostaglandins and Related Compounds
Chapter 33: Biological Membranes and Transport
Chapter 34: Free Radicals and Antioxidants
Chapter 35: Environmental Biochemistry
Chapter 36: Insulin
Chapter 37: Cancer
Chapter 38: Acquired Immunodeficiency Syndrome (AIDS)
Section Seven: Basics to Learn Biochemistry
Chapter 39: Introduction to Bioorganic Chemistry
Chapter 40: Overview of Biophysical Chemistry
Chapter 41: Tools of Biochemistry
Chapter 42: Immunology
Chapter 43: Genetics
Appendix
Index

Preface

This book of ‘Biochemistry’ is undoubtedly one of the most widely read books by both students and teachers of medicine, biology, and other allied sciences (in India and many other countries). It is truly an excellent book and a true companion for all biochemists; hence, it deserves to be considered by many as the ‘Bible of Biochemistry.’ Over a period of thirteen years, this book has undergone three iterations and revisions.

The rapid growth of this subject has led to a corresponding increase in biological development. We should also consider critical thinking and constructive feedback from teachers and students. All this requires regular review of the book.

Review each chapter thoroughly and update it with the latest developments in this fourth edition. The focus of this text is the positive aspect of human biology and its treatment in health and disease. We have also added various experimental and biochemical models, along with reviews and discussions. In addition, many new biological properties are reported in this article, some of which are listed below.

• Triacylglycerol/fatty acid cycle

• Metabolic syndrome

• Glucose toxicity

• Estimated average glucose

• Peptide nucleic acids

• Pseudogenes

• Recombinant ribozymes

• Epigenetic regulation of gene expression

• Metagenomics

• Therapeutic diets

• Atkins diet

• Dietary antioxidants

• High fructose corn syrup

s • ω-fatty acid

• Soluble and insoluble fiber

• Trans fatty acids

• Nutrigenomics

• Detailed information on antivitamins

• Dental caries

• Amino acids as neurotransmitters

• Disorders of membrane transport

• The diagnostic importance of various body fluids and tissues

• Enzyme patterns in diseases

• Cystatin C

• Pleural fluid

• Highly sensitive It is a fact that I represent a select group of individuals who author books and have some free time, in addition to hard work, determination, and dedication. I consider myself an eternal reader and a regular student of biochemistry.

However, the exponential growth of the subject makes it impossible for me to keep up with the ever-growing advances in biochemistry. This situation fills me with anxiety every time I consider revising the book. I honestly and frankly admit that I have to depend on mature readers for subsequent editions of this book. The article’s readers, well-wishers, and experts must understand that I can’t always meet them and hear their opinions.

I sincerely invite readers, well-wishers, and biologists to feel free to write to me (email ID: uppalasatya@yahoo.com) to express their honest views, critical opinions, and constructive comments. This will also help me improve the book in the next review.

Biology is perhaps the most fascinating subject because it refers to the chemical expression of life, be it humans, animals, plants, or microbes. No other branch of science has as much application as biology in the fields of medicine, health, veterinary medicine, agricultural bioengineering, and technology. This requires a completely different approach to the biochemistry literature.

There are many biology books on the market. Some books only hold significance when combined with others, and only a few comprehensively cover both topics. Therefore, students studying biology have to rely on many books to gain comprehensive knowledge of the subject during college classes.

This book, ‘Biochemistry,’ is unique and focuses on the fundamentals and applications of biology. This book is basically a combination of medical science and quality, written entirely to meet the requirements of undergraduate courses in medicine, dentistry, pharmacy, health sciences, and other fields (agriculture, veterinary medicine, etc.) where students study biology as one of the basic sciences.

What is common among students (especially in medicine) is to view organisms as normal metabolic pathways that are useful and uncomplicated. This book offers a fresh look at biochemistry so that students can grasp the relevance of biological applications in medicine.

This book aims to foster a sustained interest and enthusiasm in students, encouraging them to learn and develop biochemistry concepts in a logical and step-by-step manner. It incorporates a variety of pedagogic aids, besides color illustrations, to help the students understand the subject quickly and to the maximum. The summary and biomedical/clinical concepts aim to facilitate a swift assimilation of biochemistry facts and concepts.

The self-assessment exercises will stimulate the students to think rather than merely learn the subject. In addition, these exercises (essays, short notes, fill in the blanks, and multiple-choice questions) set at different difficulty levels will cater to the needs of all the categories of learners.

It is inappropriate to explain how and when the book came to be here. I wrote the entire book in the early hours of the morning (between 2 and 6 a.m., when most people are asleep), using this time for intellectual work. Having fresh thoughts and new ideas after a good night’s sleep greatly aided me in writing this book. My wife begged me not to write about diabetes, cancer, and AIDS at home. According to him, I made every effort to write these articles during my free time at the department. However, when I reread them in the peaceful hours of the morning, I was disappointed and had to rewrite them. Indeed, I conceived each page of this book in the darkness and gave birth to it at dawn! This textbook is a distillation of my knowledge and teaching experience in biochemistry, acquired during the past 25 years. It contains predigested information on biochemistry for excellent understanding, assimilation, and reproducibility. A fine eye crafts each page. The ultimate goal of this book is to provide the reader with a comprehensive understanding of biochemistry, covering both basic and applied aspects.

Even though I did my best to make the book error-free, I was not wrong. I welcome feedback, criticism, and suggestions from teachers and students.

Download For Free in PDF Format

Download Now